精准快速！岛津临床质谱助力26种抗癫痫药物血药浓度监测

<p><img class="rich_pages wxw-img" data-fileid="100009936" data-ratio="0.19555555555555557" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="jpeg" data-w="900" style="white-space: normal;" /><img class="rich_pages wxw-img" data-fileid="100009938" data-ratio="0.19122257053291536" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="gif" data-w="638" style="white-space: normal;" /></p><section style="box-sizing: border-box;font-size: 16px;"><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(255, 169, 0);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;max-width: 100%;height: auto;box-sizing: border-box;"><section style="margin: 2px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="color: rgb(62, 62, 62);line-height: 1.3;box-sizing: border-box;"><p><span style="font-size: 17px;color: rgb(0, 0, 0);"><strong>导读</strong></span></p></section></section></section></section></section><section style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">癫痫病（Epilepsy）在我国又被称为“羊角风”，是一种慢性脑功能障碍综合征，多发病于儿童时期，发病后若不及时控制可留下脑损伤后遗症，影响智力发育。</span></section><section style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">目前临床上常用的抗癫痫药物大多治疗窗较窄，个体差异较大，为了有效控制和治疗癫痫病情，减少毒副作用，AGNP精神科治疗药物监测共识指南强烈推荐在抗癫痫药使用过程中开展血药浓度监测，以帮助患者制订个体化给药方案，降低中毒风险，提高治疗效果。</span></section><p style="text-align: center;"><img class="rich_pages wxw-img" data-cropselx1="0" data-cropselx2="578" data-cropsely1="0" data-cropsely2="437" data-galleryid="" data-ratio="0.803125" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="jpeg" data-w="1280" style="width: 578px;height: 464px;" /></p><p><br /></p><section style="box-sizing: border-box;font-size: 16px;"><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(255, 169, 0);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;max-width: 100%;height: auto;box-sizing: border-box;"><section style="margin: 2px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="color: rgb(62, 62, 62);line-height: 1.3;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(0, 0, 0);"><strong style="box-sizing: border-box;">岛津方案</strong></span></p></section></section></section></section></section><p style="font-family: 0 0 0;text-align: center;font-size: 14px;font-family: DengXian;color: rgb(0, 0, 0);white-space: normal;line-height: 25px;"><span style="font-size: 15px;color: rgb(0, 0, 0);"><strong>适用于临床样本的26种抗癫痫药物联合检测方法</strong></span></p><p style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">市场上治疗癫痫的药物种类繁多，为了提高检测的通量和灵敏度，LC-MS/MS检测法在行业内备受青睐，为满足抗癫痫药物血药浓度监测的国内市场需求，岛津公司开发了26种抗癫痫药物联合检测方案，</span><span style="font-size: 15px;color: rgb(255, 169, 0);"><strong>只需1针进样，5分钟内完成分析，</strong></span><span style="font-size: 15px;color: rgb(0, 0, 0);">大大提高了分析效率和检测通量。</span></p><p style="text-align: center;"><span style="font-size: 14px;color: rgb(0, 0, 0);"><strong>26种抗癫痫药物色谱图</strong></span></p><p style="text-align: center;"><img class="rich_pages wxw-img" data-croporisrc="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-cropx1="0" data-cropx2="1872" data-cropy1="29.148788927335637" data-cropy2="913.3287197231833" data-galleryid="" data-ratio="0.47129629629629627" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_jpg/bnwtS5l4yfZhfDiaCOI8IT6PVTE8AwJn0r0VB0Ad... data-type="jpeg" data-w="1080" style="width: 578px;height: 273px;" /></p><p style="text-align: center;"><br /></p><p style="text-align: center;"><span style="font-size: 14px;color: rgb(0, 0, 0);"><strong>岛津临床质谱</strong></span></p><p style="text-align: center;"><img class="rich_pages wxw-img" data-galleryid="" data-ratio="0.3755725190839695" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="png" data-w="1310" style="" /></p><p style="line-height: 1.75em;text-align: center;"><span style="font-size: 14px;color: rgb(136, 136, 136);">LCMS-8050CL</span></p><p style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">样本前处理和分析性能：采用同位素内标蛋白沉淀法提取人血清中26种抗癫痫药物，通过LC-MS/MS内标法定量分析。</span><span style="font-size: 15px;color: rgb(255, 169, 0);"><strong>0.5μL进样量下的LLOQ信噪比&gt;30，线性相关系数&gt;0.9992，</strong></span><span style="font-size: 15px;color: rgb(0, 0, 0);">质控品准确度在86.3~113.2%内，精密度RSD(n=6)在0.61~5.52%内，分析性能满足临床检测要求。</span></p><p style="margin-bottom: 7.8px;text-align: center;font-variant-numeric: normal;font-variant-east-asian: normal;font-stretch: normal;font-size: 9px;line-height: normal;font-family: &quot;PingFang SC&quot;;color: rgb(0, 0, 0);white-space: normal;"><span style="font-size: 14px;color: rgb(0, 0, 0);"><strong>表1. 抗癫痫药物血清基质校准品和质</strong><strong>控品相关分析性能</strong></span></p><p style="text-align: center;"><img class="rich_pages wxw-img" data-cropselx1="0" data-cropselx2="578" data-cropsely1="0" data-cropsely2="834" data-galleryid="" data-ratio="1.1878557874762807" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="png" data-w="1054" style="width: 578px;height: 687px;" /></p><p style="margin-bottom: 7.8px;text-align: left;font-variant-numeric: normal;font-variant-east-asian: normal;font-stretch: normal;font-size: 9px;line-height: normal;font-family: &quot;PingFang SC&quot;;color: rgb(0, 0, 0);white-space: normal;"><span style="font-size: 12px;color: rgb(0, 0, 0);">*线性拟合采用1/C加权,R&gt;0.9992</span></p><p style="margin-bottom: 7.8px;text-align: center;font-variant-numeric: normal;font-variant-east-asian: normal;font-stretch: normal;font-size: 9px;line-height: normal;font-family: &quot;PingFang SC&quot;;color: rgb(0, 0, 0);white-space: normal;"><span style="font-size: 14px;color: rgb(0, 0, 0);"><strong>Volex色谱柱适用复杂组分的分离分析</strong></span></p><p style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">Velox实心核表面多孔颗粒系列色谱柱（Shim-pack Volex PFPP (50 mm x 2.1 mm I.D., 2.7 μm),P/N：227-32021-02,岛津（上海）实验器材有限公司）兼顾色谱分离效率和耐受性设计，在5分钟内实现26种抗癫痫药物快速分离。</span></p><p style="text-align: center;"><img class="rich_pages wxw-img" data-backh="175" data-backw="578" data-cropselx1="0" data-cropselx2="578" data-cropsely1="0" data-cropsely2="176" data-galleryid="" data-ratio="0.3111111111111111" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="png" data-w="900" style="width: 578px;height: 180px;" /></p><p style="line-height: 1.75em;text-align: center;"><span style="font-size: 14px;color: rgb(0, 0, 0);">部分化合物基质样本定量限色谱图（流动相：5 mM甲酸铵水；甲醇/乙腈=1/1）</span></p><p style="line-height: 1.75em;"><br /></p><section style="box-sizing: border-box;font-size: 16px;"><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(255, 169, 0);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;max-width: 100%;height: auto;box-sizing: border-box;"><section style="margin: 2px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="color: rgb(62, 62, 62);line-height: 1.3;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(0, 0, 0);"><strong style="box-sizing: border-box;">结语</strong></span></p></section></section></section></section></section><p style="line-height: 1.75em;"><span style="font-size: 15px;color: rgb(0, 0, 0);">岛津临床质谱可以轻松应对26种抗癫痫药物血药浓度联合检测的需求，解决临床TDM监测灵敏度低、抗干扰能力弱、检测通量小的难点，助力抗癫痫药物血药浓度监测。&nbsp;</span></p><p><br /></p><section style="white-space: normal;line-height: 2em;"><span style="color: rgb(136, 136, 136);font-family: Calibri, sans-serif;font-size: 15px;text-align: left;text-indent: 29px;">文中推荐技术方法方案仅用于医学专业人士技术交流，不作为临床诊断依据。</span></section><section style="white-space: normal;line-height: 2em;"><span style="font-family: Calibri, sans-serif;text-align: left;text-indent: 29px;color: rgb(136, 136, 136);font-size: 15px;"></span><br /></section><p style="white-space: normal;"><img class="rich_pages wxw-img" data-fileid="100009943" data-ratio="1.1185185185185185" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="png" data-w="1080" /></p><p style="white-space: normal;"><img class="rich_pages wxw-img" data-fileid="100009942" data-ratio="0.09702660406885759" data-s="300,640" data-src="https://miniapp.shimadzu.com.cn/sites/default/files/users/user42/1639579... data-type="gif" data-w="639" /></p>